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Some of the WHI findings were again found in a larger national study done in the UK, known as The Million Women Study. Food and Drug Administration include short-term treatment of menopausal symptoms, such as vasomotor hot flashes or urogenital atrophy, and prevention of osteoporosis.
As a result of these findings, the number of women taking hormone treatment dropped precipitously. A consensus expert opinion published by The Endocrine Society stated that when taken during perimenopause, or the initial years of menopause, hormonal therapy carries significantly fewer risks than previously published, and reduces all cause mortality in most patient scenarios.
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Coverage of the WHI findings led to a reduction in the number of post-menopausal women on hormone replacement therapy.In 2002 the Women's Health Initiative (WHI) was published.That study looked at the effects of hormonal replacement therapy in post-menopausal women.The WHI also found a reduced incidence of colorectal cancer when estrogen and progesterone were used together, and most importantly, a reduced incidence of bone fractures.
Ultimately, the study found disparate results for all cause mortality with hormone replacement, finding it to be lower when HRT was begun during ages 50–59, but higher when begun after age 60.Progesterone is the major anabolic hormone for breast tissue, and accordingly breast cancer was not increased in patients who were on estrogen therapy alone after hysterectomy.